Patient Guide: Spravato® Nasal Spray Treatment (Side Effects, Coverage, REMS, and more)

**Patient Guide: Spravato® Nasal Spray Treatment (Side Effects, Coverage, REMS, and more)** This patient-friendly guide explains what to expect before, during, and after Spravato® (esketamine) nasal spray treatment. You’ll learn how Spravato works, who it may be appropriate for, and what the treatment process looks like in a certified clinic setting. We also cover common side effects, safety precautions, and the required REMS program—including why monitoring is needed after each session and how to plan for transportation. You’ll find practical information on insurance coverage and prior authorization, typical out-of-pocket considerations, and how Mind Matters Behavioral Health can help you navigate benefits and paperwork. The guide includes tips for preparing for appointments, questions to ask your provider, and when to contact the clinic about symptoms or concerns—so you can feel informed, supported, and confident throughout your care.